Anyone tapped into the skin-care conversation right now has surely heard about exosomes, the regenerative ingredient that changes the way cells react to aging. When we published our first story about its growing presence in topical serums and creams in March 2025, it was still a burgeoning category; 17 months later, exosome skin care continues to expand.

“Exosomes sit at the intersection of several important shifts in aesthetics: regenerative medicine, cellular signaling, and a more sophisticated understanding of skin as a living organ rather than simply a surface to be treated,” board-certified plastic and reconstructive surgeon and Vogue Beauty Board member Lara Devgan, MD, explains. She says to think of them as “microscopic extracellular vesicles” that facilitate communication between cells; instead of just delivering a single ingredient into the skin, exosomes influence the way cells communicate and respond to aging.

Because of its reparative abilities, it plays a major role in the ongoing regenerative skin-care movement. However, Dr. Devgan thinks it is premature to consider them a foundational category in the same way we think about retinoids, antioxidants, or peptides.

As someone who has had a few life-changing experiences with exosome microneedling (more about my experience here), I’m really excited to see how the ingredient evolves. That said, as the next generation of exosome products are unveiled, we’re most interested in formulas that can deliver “clinically meaningful results,” as Dr. Devgan puts it: products that feature the ingredient alongside others already trusted for their efficacy—and, best-case scenario, also feel like a treat to apply.

With that, we tapped Neada Deters and Sean Garrette to test some of the latest exosome launches. Below, they share their honest thoughts from their trials. Read on to learn what’s worth trying for yourself.

Eighth Day The Overnight Eye Cream Treatment

• Why We Love It: Though Eighth Day’s The Eye Renewal Cream is a nourishing elixir apt for addressing dark circles and crow’s-feet, Antony Nakhla, MD, double-board-certified dermatologist and founder of Eighth Day, wanted to create something a bit more decadent with amplified anti-aging benefits. Meet the Overnight Eye Cream Treatment—a rich balm powered by microencapsulated retinal technology (called RetinalXR) to smooth, brighten, and firm. Furthermore, exosomes come in to stimulate collagen and elastin production—bolstered by the brand’s patented peptide-rich plasma for long-term regenerative benefits.
  Key Ingredients: RetinalXR, bioidentical exosomes, peptides, peptide-rich plasma
  Size: 5 fl. oz. / 15 mL